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Phosphatidylserine

Also known as: Phosphatidylserine (20%)

Fat-soluble amino acid derivative found in the brain that can improve memory and cognitive function and reduce stress when supplemented


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What Is It?

Phosphatidylserine (PS) is a phospholipid found in all living cell membranes that plays a prominent role in cell cycle signaling, especially apoptosis (programmed cell death). In the human body, it's predominantly found in the brain where it supports cognitive functioning.

PS is one of the phospholipids contained in soy lecithin, along with phosphotidylcholine (PC) and phosphotidylinositol (PI).

What Does It Do?

As mentioned above, phosphotidylserine is an important cell signaling molecule in the body that positively influences Na+/K+ enzymes that stimulate ATPase(upregulation), and downregulate acetylcholinesterase.This is where the cognitive benefits of phosphatidylserine stem from.

Acetylcholine is a powerful neurotransmitter in the brain often dubbed the "learning neurotransmitter." Acetylcholinesterase is the enzyme the body employs to break down acetylcholine. By downregulating the production of this enzyme, circulating levels of acetylcholine remain elevated and lead to a number of cognitive benefits including increased alertness, heightened focus, and quicker memory recall.

Phosphotidylserine is also used by athletes for improving sports performance, especially in endurance sports. Specifically, PS supplementation has been documented to increase endurance. Other exercise-oriented research indicates that it increases post-exercise testosterone levels and enhances mTOR-activity, mimicing the effects of phosphatidic acid (PA)

Lastly, PS has also been found to exert anti-anxiety benefits as well as decrease cortisol levels, furthering its stress-relieving properties.

Benefits of Phosphatidylserine

  • Enhance cognitive function
  • Increase time to exhaustion
  • Boost endurance
  • Reduce cortisol levels
  • Ease anxiety
  • Mitigate stress
  • Raise post-exercise testoserone levels
  • Enhances mTOR activity

How Much?

Research has shown the standard dosing protocol to be 100mg, consumed 3 times a day for a total of 300mg daily. Lower doses may provide some benefit, but not as much as consuming the documented 300mg employed in clinical trials.

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