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Also known as: Inositol-stabilized Arginine Silicate

Patented complex of arginine bonded to silicate that raises arginine blood levels for up to 3 hours leading to improved blood flow, greater vasodilation, and higher nitric oxide (NO) levels in the body.

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What is Nitrosigine?

Arginine supplements and arginine boosting supplements (citrulline malate, agmatine, etc) have long been the go-to supplement when looking to enhance vasodilation and create the ultimate pump. And youre probably thinking, Arginine?! Thats old news, I want something newer and better!

We dont blame you; pure arginine has proven to be less effective than other pump and Nitric Oxide (NO) boosters, but that has now changed thanks to the development of Nitrosigine.

Nitrosigine (Inositol-stabilized Arginine Silicate) is a mixture of arginine, inositol, and potassium silicate. This novel form of arginine combines the cardiac function-improving effects of both arginine and silicate in an inositol-stabilized form. The upside to this new compound is increased bioavailability of both arginine and silicate. The end result is an effective Nitric Oxide and silicon blood level booster perfect for athletes, bodybuilders and and powerlifters!

Where Does It Come From?

Nitrosigine is a trademarked product formulated exclusively by Nutrition21, a company that specializes in manufacturing dietary supplements.

What does it do?

Most likely, youre well aware of what arginine does in the body, but in case you forgot, heres a brief summary. Arginine is required by many physiological processes in the body including synthesizing creatine in the body, boosting growth hormone (GH) output, eliminating waste products, supporting immune system defense, and regulating hormone secretion. It also helps maintain appropriate salt levels in the body. Most important to workout buffs, Arginine is a precursor to Nitric Oxide (NO) which is a potent vasodilator in the body.

Silicon, on the other hand, is a relatively new and unique performance-boosting ingredient. It can strengthen and improve the flexibility of your arteries, which helps to increase blood flow and support healthy cardiovascular system functioning.Typically though it is difficult to absorb from the diet. Silicon is proposed to work by making the inner lining of the arterial wall less permeable, meaning substances cannot pass through it easily..

In a number of clinical studies, Nitrosigine has been shown to relax blood vessels, which: improves blood flow, 500% more effectively than supplementing with Arginine HCI. Improving blood flow is especially important during strenuous, high-intensity anaerobic exercise such as a weightlifting, sprinting, and jumping. Additionally, Nitrosigine increased plasma arginine levels within 30 minutes of ingestion and these heightened levels were sustained for up to 3 hours post-consumption.

The increased circulation means more blood, oxygen and nutrients make their way to your muscles allowing you to workout out longer and harder than you previously could and generate one serious PUMP!

Nitrosigine also exhibits pro-erectile properties. The improved blood flow and reinforced arterial walls can increase the duration and hardness of erections, making Nitrosigine a promising supplement for men looking for a little boost in the bedroom.

Finally, the improved blood flow can minimize occurrences of swelling, clotting, cramps and pain most commonly caused by exercise or injuries. Based on all of this information, sooner or late Nitrosigine will become a staple in nearly all pre workouts or supplement stacks in the very near future.

Benefits of Nitrosigine

  • Better Nitric Oxide production

  • Increased blood flow

  • Highly bioavailable source of arginine and silicon

  • Nitric Oxide base levels build over time

  • Better blood flow and vessel flexibility


Studies conducted on Nitrosigine dosed at 750mg to 1500mg with no ill effects reported. of Nitrosigine can dramatically increase plasma arginine levels within 30 minutes of consumption. These levels remain elevated for up to 3 hours post-consumption.

A rather unique attribute of Nitrosigine is that with continued daily use, basal Nitric Oxide levels have been shown in a clinical study to build over time, making it the ideal NO boosting product.


Theres no doubt about it, Nitrosigine is a definite game-changer in the NO booster market. A big reason for this is nutrient delivery, which plays a vital role in creating the PUMP in the body. Feeding the muscles the nutrients they need to perform, grow, and recover cant be stressed enough. Its obvious that Nitrosigine is one of the most exciting NO boosting supplements to come out in a long time and before long with be THE NO boosting product everyone turns to!

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