– Aspirin Ephedra ≠ Ephedrine
Use the 20/200
rule (20mg Ephedrine for every 200mg Caffeine)
Aspirin is optional and if taken should be dosed with baby aspirin (81mg)
As far as I know, there is no scientific reason to cycle ECA.Ingredient Information:
– Ideally, you want to use Ephedrine HCl. Bronkaid, Primatene, and Ephedrine Sulfate can also be used.Caffeine
– Using 100mg tablets would be useful for the first week or two. Most 200mg tablets can be split easily using fingers or a pill cutter.Aspirin
– Baby aspirin (81mg), but, again, it is not necessary to have great results from this stack.Scientific Research:
Ephedrine is a sympathomimetic (definition below) drug prescribed as a nasal decongestant, with properties similar to epinephrine. Its effects on both a- and b-adrenergic receptors and its central effects resemble those of amphetamines
Sympathomimetic: a pharmacologic agent that mimics the effects of stimulation of organs and structures by the sympathetic nervous system. It functions by occupying adrenergic receptor sites and acting as an agonist or by increasing the release of the neurotransmitter norepinephrine at postganglionic nerve endings.
A combination of caffeine and ephedrine has shown to be effective in long-term weight management, likely due to different mechanisms that may operate synergistically, e.g., respectively inhibiting the phosphodiesterase-induced degradation of cAMP and enhancing the sympathetic release of catecholamines.
This paper describes a 24-week open follow-up trial with reduced obese patients all receiving an ephedrine/caffeine combination (20 mg/200 mg) three times a day. The study was a continuation of a previous 24-week double-blind placebo-controlled study where the ephedrine/caffeine mixture had shown superior weight-reducing properties when compared with either ephedrine alone (20 mg) or caffeine alone (200 mg) three times a day. The medication was stopped between weeks 24-26 in order to evaluate withdrawal symptoms. The follow-up period was from weeks 26 to 50. Of 127 patients included, 99 completed the follow-up treatment, which resulted in an additional weight loss of 1.1 kg (P = 0.02). Adverse drug reactions were all minor and temporary. We conclude that the ephedrine/caffeine combination is safe and effective in long-term treatment in improving and maintaining weight loss. The side-effects are minor and transient and no clinically relevant withdrawal symptoms have been observed.
The thermogenic effect after E+C (20 mg/200mg) was larger than that of any other combinations, and E and C exerted a supra-additive synergism on thermogenesis and systolic blood pressure, while being without effect on diastolic blood pressure. The combination also had pronounced effects on glucose metabolism by increasing plasma glucose, insulin and C-peptide concentrations. During chronic treatment the effect of E+C on energy expenditure is maintained, while side effects subside because tolerance develops to its hemodynamic and metabolic effects. During dietary energy restriction E+C promotes fat loss and preserves fat-free mass, which may contribute to its chronic effect on energy balance. In conclusion, the hemodynamic and side effects to E+C are transient during chronic treatment, while the effect on energy expenditure persists. The compound also possesses repartitioning properties, which may be useful in the treatment of obesity.
Animal and human studies have suggested a thermogenic synergism between ephedrine (E), a beta-agonist, and caffeine (C), an adenosine antagonist, which may be suitable for the treatment of obesity. To study this phenomenon, the thermogenic effect of single doses of oral placebo, E 10 mg, E 20 mg, C 100 mg, and C 200 mg were compared with the effects of three different combinations of E + C, 10 mg/200 mg, 20 mg/100 mg, and 20 mg/200 mg, measured by indirect calorimetry in six healthy, lean subjects. The thermogenic effect after E + C 20 mg/200 mg was larger than that of any of the other combinations. In this dose ratio, ephedrine and caffeine exerted a supra-additive synergism, whereas the thermogenic effects of the other two combinations were only additive. The 3-hour postintake increase in systolic blood pressure after all three combinations averaged 5 to 7 mm Hg more than placebo (P less than .01), which exceeded the predicted additive effect fivefold to sevenfold. Diastolic blood pressure was not increased by E + C 20 mg/200 mg, whereas the other two combinations increased it by approximately 4 mm Hg more than placebo.
All three beta-adrenoceptor subtypes (beta 1, beta 2 and beta 3) may be involved in ephedrine-induced thermogenesis, but the resistance to complete inhibition by the non-selective antagonist nadolol indicates that at least 40% of the response is mediated by an atypical receptor, which is presumed to be the beta 3-adrenoceptor.
Ephedrine works by stimulating the release of the body’s own noradrenaline, which stimulates all the adrenergic receptors. The stimulant side effects subside because they are primarily mediated by the beta-1 and beta-2 receptors, which downregulate during chronic use. Thus, the scientists were startled when they found that the thermogenic effect actually increased with chronic use.
The side effects of ECA will diminish after a while, but the thermogenesis will continue on.Dosing Schedule for 8mg tablets:
(Kaizen, 4Ever Fit)
*Add in 81mg of aspirin per serving if you choose to include it.
Dosing Schedule for 20-25mg tablets:
|Day 1 ||8mg(E) + 100mg(C)|
|Day 2-3 ||8mg(E) + 100mg(C)||8mg(E) + 100mg(C) ||8mg(E) + 100mg(C)|
|Day 4-6 ||16mg(E) + 200mg(C)||8mg(E) + 100mg(C) ||8mg(E) + 100mg(C)|
|Day 7-8 ||16mg(E) + 200mg(C)||16mg(E) + 200mg(C) ||8mg(E) + 100mg(C)|
|Day 9-11 ||16mg(E) + 200mg(C)||16mg(E) + 200mg(C) ||16mg(E) + 200mg(C)|
|Day 12-14 ||24mg(E) + 200mg(C) ||24mg(E) + 200mg(C) ||16mg(E) + 200mg(C)|
|Day 15+ ||24mg(E) + 200mg(C) ||24mg(E) + 200mg(C) ||24mg(E) + 200mg(C)|
½E = Half the ephedrine dose, e.g. – 12mg
|Day 1 ||½(E) + 100mg(C) |
|Day 2-3 ||½(E) + 100mg(C) ||½(E) + 100mg(C) ||½(E) + 100mg(C)|
|Day 4-7 ||20-25mg(E) + 200mg(C) ||½(E) + 100mg(C) ||½(E) + 100mg(C)|
|Day 8-14 ||20-25mg(E) + 200mg(C) ||20-25mg(E) + 200mg(C) ||½(E) + 100mg(C)|
|Day 15+ ||20-25mg(E) + 200mg(C) ||20-25mg(E) + 200mg(C) ||20-25mg(E) + 200mg(C)|
•Try to take the doses 30 minutes before your meal.
•Watch your stimulant intake from other products (PWOs, Soda, Tea, Coffee, etc.)
•You can take it before working out, but 1) take a smaller dose, 2) don’t take a PWO that has stimulants, 3) keep your heart rate lower than normal and that also means no HIIT.
•Taking it twice a day is still effective. This will keep you up at night and sleep is very important, so don’t sacrifice sleep time in order to fit three doses in.
•It’s recommended not to take it if you’re going to be working in the heat. Everyone’s different, but I do manual labor outside and I’ve been slaving away in 90° heat and I’m still here writing this, but I did get lightheaded frequently and I also drank a gallon of water every 5-6 hours of work along with food that is high in electrolytes which brings me to my next point…
•Potassium is important to keep up on this. Don’t take a potassium supplement, just get it from food. You can google foods to find what has good levels of K+
•Don’t be stupid and exceed the dosage (e.g. taking 4 doses/day or taking more than 25mg of ephedrine per serving)
•It’s recommended to take fish oil with this to help with BP. Strive for 2+ grams/day.
•ECA is supposed to work best when on a low-carbohydrate diet.
•Drink plenty of water while using this stack. Thermogenesis means you are going to sweat more and lose more water. Caffeine is a diuretic as well, adding to the water loss.Side Effects:
•Do not run the ECA cycle if you have heart problems, high blood pressure, are taking SSRIs, SNRIs, MAOI, or other forms of antidepressants, or if you’re pregnant.
•Remember to listen to your body
and stop if you think anything is wrong.
•You will most likely become addicted to caffeine after this so remember to taper off caffeine to keep the headaches at bay. Ephedrine can be cut cold-turkey.
•People have died
from ephedrine and caffeine. Don’t be an idiot.
•You should be 18+
to consider running this.Information on the ECY stack:
Yohimbine HCl is added to Ephedrine and Caffeine Yohimbine ≠ Yohimbe
Personally, I would not recommend doing the ECY stack, but if you are just so inclined to do it, go ahead and google how to run it. It would appear that the E+Y combination can be dangerous for your body. Yohimbine and Caffeine is a much better route to take if you are set on using yohimbine. There is a a bb.com thread about ECY you can google if you’re interested…
An excerpt from that thread: (Not saying this is true because I really don’t know if it is, just thought-provoking)
NOTE: It is research-documented that alpha-2 adrenoreceptor antagonism initiates a cascade that diminishes beta-adrenoreceptor mediated lipolysis (re: fat burning). Remember, ephedrine is a beta-receptor agonist, so by taking E + Y together, you're basically taking three steps forward and then one step back. Perhaps even more importantly E & Y together = a ton of central norepinephrine relay to the HPTA, which is EXTREMELY bad for you long-term for the following reasons: 1. extremely vasoconstrictive, both in sections of the brain and periperhally, 2. (from 1) there will be a significant elevation in blood pressure, 3. the HPTA (hypothalamus-pituary-thyroid-axis) is basically the 'master control switch' for an innumerable number of the body's metabolic and endocrine processes. Whereas dopamine and serotonin convey to the HPTA that there is positive energy influx, NE/NA (norepinephrine) is a stress-hormone, which is perfectly fine in the short-term for reducing appetite, providing energy while hypocaloric, and causing weight loss. Too-much continual stress-hormone signaling to the HPTA means your body thinks it's starving, seriously. That's why--short term, Y + E work fine. Long-term, they will diminish fat-loss, because they will literally **** over your metabolism from top to bottom. You need to achieve neurotransmitter/catecholamine balance: epinephrine: norepinephrine: dopamine. Taking E + Y together radically tilts the scale in the direction of norepinephrine, which, as I said, will diminish lipolysis long-term and will eventually bring your diet to a screeching halt (unless you are using an exogenous source of dopamine like nicotine to correct this deficiency, and even here, I still do not recommend the pairing based on the other aforementioned reasons). Again, think about it, I'm talking about your HPTA. So that includes a.) thyroid, b.) pituitary (which releases GnRH which, downstream, regulates testosterone levels), c.) hypothalamus (your body's primary 'control panel'). These are not components in your body that should be taking lightly. This is why so many contest dieters are forced to take cytomel, or cannot get their dick hard: because their body is so convinced that they are starving that their HPTA-regulated processes have entirely bottomed out. I sincerely hope everyone can see the significance of this, in terms of the "big picture."
Always remember, there’s no sense in taking weight loss supplements if your diet and exercise routine are not already in check!
If anyone has any other information they'd like to know I'd be glad to research it and add it!
*I'm not sure what the rules are about posting sources for ephedrine so for now I won't post where I purchased mine. If an admin wants to chime in and let me know that would be appreciated.