Author Topic: Difference btw diphenhydramine and doxylamine succinate  (Read 8397 times)

Raptorbh12

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Difference btw diphenhydramine and doxylamine succinate
« on: March 02, 2010, 08:13:01 AM »
As the title asks, what is the difference between benadryl (diphenhydramine) and unisom (doxylamine succinate).
Benadryl can be used to upregulate receptors after or during stimulant usage but does doxylamine work through the same pathways and in turn also up regulate receptors.
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garlick

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #1 on: March 02, 2010, 08:46:06 AM »
The true difference between the two is the addition of a Hydrogen and Nitrogen molecule, as doxylamine succinate is written, C17H22N2O, where as Diphenhydramine is written C17H21NO.

Now the bonds do change when you add the additional molecules. Specifically, the extra Nitrogen attaches more regularly to the Carbon making it more stable.

Doxylamine Succinate is actually more powerful in this regard, because it's less likely to breakdown upon ingestion.

This actually means it might be better than Benadryl in receptor regulation. This also means there's a higher possibility of overdose, and some more severe side effects when taking Doxylamine Succinate.

Still, it will work on the same nuero pathways in your system.

petey7408

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #2 on: March 02, 2010, 09:02:07 AM »
Very interesting....

Would you recommend one over the other, and have you tried both?
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garlick

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #3 on: March 02, 2010, 09:05:36 AM »
Very interesting....

Would you recommend one over the other, and have you tried both?

Personally, I would definitely stick with Benadryl, but that's only because these regulators effect me pretty strongly to begin with, so I'm extremely drowsy after taking these at night, and I have to be bright eyed and bushy tailed at 5:30 AM everyday.

If you have no issues with drowsiness on Benadryl, then I would say give Unisom a try.

Raptorbh12

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #4 on: March 02, 2010, 10:19:41 AM »
single doses of unisom work for me and it can take 2-2.5 doses of benadryl to incurr drowsiness.
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garlick

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #5 on: March 02, 2010, 10:33:50 AM »
single doses of unisom work for me and it can take 2-2.5 doses of benadryl to incurr drowsiness.

If I took 2-2.5 doses of Benadryl, I would be knocked out for 16 hours, and when I wake up, it would take 3-4 cups of coffee just to feel normal again.

My body is that sensitive to the stuff.

Raptorbh12

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #6 on: March 02, 2010, 10:47:40 AM »
Yea I can take 4 benadryls and not sleep for 3 more hours, very little affect. Unisom hits me hard and fast, love the stuff.
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AbsoluteZ3R0

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #7 on: March 02, 2010, 11:55:12 AM »
Yea I can take 4 benadryls and not sleep for 3 more hours, very little affect. Unisom hits me hard and fast, love the stuff.

Same here, 4 benadryl tablets did almost nothing for me in terms of inducing drowsiness. Haven't tried anything else though

petey7408

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Re: Difference btw diphenhydramine and doxylamine succinate
« Reply #8 on: March 02, 2010, 12:02:03 PM »
I was wondering about that. I take 2 capsules and don't really get that drowsy feeling.
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